A Logical Approach to Homeopathy Based on Scientific Research

By Madeleine Bastide, Honorary Professor, University Montpellier 1, France

The value of a logical model is related to the possibility of experimental verifications. We propose an epistemological approach of homeopathy based on an informative process heard and interpreted by the living organism. Results observed in basic experimental research confirm this information paradigm that respects the three principles of Homeopathy.

CURRICULUM VITAE

Madame Madeleine BASTIDE, née le 19/03/35
Mariée, 4 enfants

Titres Universitaires
- Diplôme de Pharmacien, Montpellier
- Certificat d'Etudes Spéciales de Sérologie, .de Bactériologie, de Chimie Biologique
- Docteur d'Etat en Pharmacie, Montpellier, 1965.
- Lauréate de la Faculté de Pharmacie (Prix Hébrard), 1966.
- Physiologie, Toxico et Pharmacologie cellulaires, Ecole Pratique des Hautes-Etudes, Paris,
- Agrégation, option Immunologie, Paris.
Fonctions Universitaires
- Chef de laboratoire de Sérologie,- Assistante titulaire de Microbiologie, Chef de Travaux Pratiques titulaire de Bactériologie, Maître-Assistant de Bactériologie, .Maître-Assistant d'Immunologie , Maître de Conférences agrégé d'Immunologie , Professeur d’Immunologie , Professeur Classe Exceptionnelle, Professeur Emérite Université Montpellier I,
- - Professeur Honoraire Université Montpellier I depuis Septembre 2000
Membre de sociétés Savantes
- Société Française de Mycologie Médicale
- International Society of Immunopharmacology
- International Society of Neuro Immunology
- International Society of Neuro Immunomodulation
Autres Fonctions
- Expert auprès de la Commission Nationale de Pharmacopée (arrêté du 25 Juillet 1990).
- Membre du Groupe d'Experts (Homeopathic Medicine Research) - Direction Générale XII (Science, Recherche et Développement) - Commission Européenne (Bruxelles) de 1993 à 1997).
- Lauréate 1er prix international (1992-1993) "Rafael Lopez Hinojosa" (Recherche Scientifique en Homéopathie) - Mexico - Décembre 1994
- Membre du Groupe de Travail des Médicaments Homéopathiques de la Commission des AMM, AgenceFrançaise de Sécurité Sanitaire des Produits de Santé (AFSSAPS), depuis 1998.
- Médaille de Vermeil 2000, Société d’Encouragement au Progrès, remise le 13 Janvier 2001 au Palais du Luxembourg, Paris, par Mr Yves Coppens, Professeur au Collège de France.


PUBLICATIONS SCIENTIFIQUES

Papers published in International Journals: 102
1-40 on Microbiology, then on Immunology or High dilution effects as follows :
40- Doucet-Jaboeuf M, Guillemain J, Piechaczyk M, Karouby Y, Bastide M
Evaluation de la dose limite d'activité du facteur thymique sérique. CR Acad Sci, 1982 ; 295 : 283-286.
41- Jouvert S, Lebecq JC, Bastide M
Etude cytologique en microscopie électronique à balayage de l'action de facteurs sériques sur Candida albicans.
Bull Soc Fr Mycol Med, 1984 ; 13 : 167-172.
42- Doucet-Jaboeuf M, Pélegrin A, Cot MC, Guillemain J, Bastide M
Seasonal variation in the humoral immune response in mice following administration of thymic hormones.
Annual Review of Chronopharmacology, 1984 ; 1 : 231-234.
43- Bastide M, Doucet-Jaboeuf M, Daurat V
Activity and chronopharmacology of very low doses of physiological immune inducers.
Immunol Today, 1985 ; 6 : 234-235.
44- Joram C, Desboeuf J, Astoin J, Bastide M
Protective activity of a cell-wall extract from Pichia fermentans. Int J Immunopharmacol, 1985 ; 7 : 304.
45- Doucet-Jaboeuf M, Pélegrin A, Sizes M, Guillemain J, Bastide M
Action of very low doses of biological immunomodulators on the humoral immune response in mice.
Int J Immunopharmacol, 1985 ; 7 : 312.
46- Bastide M, Daurat V, Doucet-Jaboeuf M, Pélegrin A, Dorfman P
Immunomodulatory activity of very low doses of thymulin in mice. Int J Immunother, 1987 ; 3 :191-200
47- Castex F, Jouvert J, Bastide M
Visualisation par microscopie électronique à balayage du transit intestinal de Saccharomyces boulardii chez la souris. Bull Soc Fr Mycol Med, 1987 ; 16 : 249-256.
48- Mallié M, Jouvert S, Lebecq JC, Bastide M, Bastide JM
Comparaison de l'activité antifongique in vitro du R 14-476/002, de l'oxiconazole, du miconazole et du terconazole : étude de la CMI et des modifications cytologiques révélées par microscopie électronique à balayage.
Bull Soc Fr Mycol Med, 1987 ; 16 : 263-268.
49- Piechaczyk M, Bouanani M, Salhi SL, Baldet L, Bastide M, Pau B, Bastide JM
Antigenic domains on the human thyroglobulin molecule recognized by autoantibodies in patient's sera and by natural autoantibodies isolated from the sera of healthy subjects.
Clin Immunol Immunopathol, 1987 ; 45 : 114-121.
50- Carrière V, Hublot B, Bastide M
Effect of pichilan on the chemiluminescence produced by murine macrophage.
Leucocyte Culture Conference, La Grande Motte, 19-24 Juin 1987. Immunobiology; 1987 ; 3 : 44-45.
51- Carrière V, Dorfman P, Bastide M
Evaluation of various factors influencing the action of mouse a,ß interferon on the chemiluminescence of mouse peritoneal macrophages. in : Reinberg A, Smolensky M, Labrecque G (Eds), Ann Rev Chronopharmacol, New York, Pergamon Press, 1988 ; 5 : 9-12.
52- Daurat V, Dorfman P, Bastide M
Immunomodulatory activity of low doses of interferon a,ß in mice. Biomed Pharmacother, 1988 ; 42 : 197-206.
53- Mallié M, Jouvert S, Bastide M, Montès B, Lebecq JC, Bastide JM
Activité comparée de 8 composés azolés sur Candida albicans : pouvoir fongistatique et cytologie en MEB.
Path Biol, 1988 ; 36 : 299-304.
54- Carrière V, Dorfman P, Florentin I, Bastide M
Adherent LGL without NK activity modulate the chemiluminescence of mouse peritoneal macrophages stimulated in vitro by a,ß interferon. Int J Immunopharmacol, 1988 ; 10 : 23.
55- Bastide M, Mallié M, Jouvert S, Montès B, Bastide JM
Activité in vitro de l'itraconazole sur diverses espèces de Candida. Path Biol, 1989 ; 37 : 694-699.
56- Bouanani M, Piechaczyk M, Pau B, Bastide M
Antigenic regions on the human thyroglobulin molecule recognized by natural autoantibodies isolated from the plasma of healthy subjects. Clinical Rheumatology, 1989 ; 8 : 10-11.
57- Bouanani M, Piechaczyk M, Pau B, Bastide M
Significance of recognition of certain antigenic regions on the human thyroglobulin molecule by natural autoantibodies from healthy subjects. J Immunol, 1989 ; 143 : 1129-1132.
58- Boudard F, Bastide M
Immunomodulatory activity in vitro of calcitonin gene-related peptide and vasoactive-intestinal peptide.
J Immunol Immunopharmacol, 1989 ; 9 : 132.
59- Castex F, Corthier G, Jouvert S, Elmer GM, Guibal J, Lucas F, Bastide M
Prevention of experimental pseudomembranous cecitis by Saccharomyces boulardii : Topographical histology of the mucosa, bacterial counts and analysis of toxin production. Microecology and Therapy, 1989 ; 19 : 241-250.
60- Carrière V, Bastide M
Influence of mouse age on PMA-induced chemiluminescence of peritoneal cells incubated with a-ß-IFN at very low and moderate doses. Int J Immunoth 1990 ; 6 : 19-23
61- Boudard F, Bastide M
Immunomodulatory activity in vitro of calcitonin gene-related peptide and vasoactive intestinal peptide.
J Immunol Immunopharmacol 1990 ; 10 : 122-123
62- Piechaczyk M, Bouanani M, Salhi SL, Bastide JM, Bastide M, Pau B
Epitopic specificities of anti-thyroglobulin autoantibodies. Nucl Med Biol-Int JR Rad app B 1990 ; 17 : 719-722
63- Piechaczyk M, Bouanani M, Bastide M, Bastide JM, Pau B
Cartographie antigénique de la thyroglobuline humaine. Intérêt dans la compréhension des mécanismes auto-immuns. Immunoanal Biol Spec 1990 ; 21 : 29-32
64- Bastide M
Réponse immunitaire à médiation cellulaire.
in : Immunologie, Encyclopédie de l'Etudiant en Médecine, D Vuitton Ed. Me'dsi/Mc Graw-Hill, 1990
65- Boudard F, Bastide M
Inhibition of mouse T-cell proliferation by CGRP and VIP : Effects of these neuropeptides on IL-2 production and cAMP synthesis. J Neurosc Res 1991 ; 29 : 29-41.
66- Boudard F, Bastide M
Modulation of the mitogenic response of murine T lymphocytes by CGRP-SP and VIP-SP combinations.
Int J Immunother 1991 ; 7 : 153-160.
67- Bouanani M, Bataille R, Klein B, Pau B, Bastide M
Conserved natural humoral immunity to thyroglobulin in patients with multiple myeloma.
British J Haematol, 1992 ; 81 : 62-6.
68- Bouanani M, Hanin V, Bastide M, Pau B
New antigenic clusters on human thyroglobulin defined by an expanded panel of monoclonal antibodies.
Immunology Letters, 1992 ; 32 : 259-64.
69- Vallot N, Boudard F, Cabaner C, Poindron P, Bastide M
Action of pichilan on nitrite production by a long-term cultured resident macrophage line.
Pathobiology, 1992 ; 60 : 35.
70- Bastide M, Lagache A
The paradigm of signifiers. Ed. Atelier Alpha Bleue, Paris, 1992, 103 pp.
71- Youbicier-Simo BJ, Boudard F, Mekaouche M, Bastide M, Baylé JD
Effects of embryonic bursectomy and in ovo administration of highly diluted bursin on adrenocorticotropic and immune responses of chickens. Int J Immunother 1993 ; 9 : 169-180.
72- Bousquet-Rouaud R, Castex F, Costalat G, Bastide M, Hedon B, Bouanani M, Jouvert S, Mirouze F
Factors involved in catheter obstruction during long-term peritoneal insulin infusion.
Diabetes Care 1993 ; 16 : 801-805.
73- Vallot N, Boudard F, Bastide M
Effect of b (1-3) -D-glucan, pichilan, extracted from Pichia fermentans on a murine macrophage cell-line.
Intern J Immunopathol Pharmacol 1994 ; 7 : 21-35.
74- Allauzen S, Salhi SL, Piechaczyk M, Bastide M, Pau B, Bouanani M
An efficient immunization protocol for production of monoclonal antibodies against soluble human insulin.
Immunology Letters 1994 ; 40 : 1-6
75- Fougeray S, Slingeneyer A, Bastide JM, Mion C, Bastide M
Dialysis solutions buffered with lactate or bicarbonate : in vitro comparison of two dialysis solutions on human peritoneal cell growth from ESRD and non ESRD patients. Adv Perit Dial 1994 ; 10 : 235-240.
76- Boudard F, Vallot N, Cabaner C, Bastide M
Chemiluminescence and nitrite determination of MALU macrophage cell line.
J Imm Meth 1994 ; 174 : 259-268.
77- Bastide M
Immunological examples on Ultra High Dilution research. in : Ultra High Dilution, Physiology and Physics. PC Endler J Schulte eds, Kluwer Publishers Dordrecht, The Netherlands 1994 : 27-35.
78- Castex F, Jouvet S, Bastide M, Corthier G
Kinetics of appearance of intestinal lesions in mice mono-associated with a lethal or non-lethal strain of Clostridium difficile. J Med Microbiol 1994 ; 40 : 102-109
79- Bastide M, Solon M
L'infinitésimalité.
in : "Encyclopédie des Médecines Naturelles", P Cornilhot ed, Frison Roche Publisher, Paris, 1995
80- Bastide M, Lagache A
Homéopathie et Immunité.
in : "Encyclopédie des Médecines Naturelles", P Cornilhot ed, Frison-Roche Publisher, Paris, 1995
81- Lagache A, Bastide M, Lemaire-Misonne C
Le Paradigme des Signifiants : schéme d'information applicable en Immunologie et en Homéopathie.
Revue Internationale de Systémique, 1995 ; 9 : 237-249
82- Vallot N, Boudard F and Bastide M
Modulation of the NO secretion in the pichilan-activated murine macrophage cell line, MALU.
Int J Immunopathol Pharmacol 1995 ; 8 : 135-149
83- Bastide M and Boudard F
An alternative concept of immunomodulation, p. 303-316.
in : Forum on Immunomodulators, M Guenounou, John Libbey Eurotext Eds., Paris, 1995
84- Cabaner C, Boudard F, Bastide M
Modulation of the proliferative response of murine Peyer's patch lymphocytes by different peptides : CCK-8, CGRP, CCK-PZ and VIP. Preliminary results. Int J Immunopathol Pharmacol 1995 ; 8 : 123-133
85- Teresi S, Boudard F and Bastide M
Effect of Calcitonin Gene-Related Peptide and Vasoactive Intestinal Peptide on murine CD4 and CD8 T cell proliferation. Immunol Letters, 1996, 50: 105-113
86- Youbicier-Simo BJ, Boudard F., Mekaouche M., .Baylé J.D, Bastide M.: A role for Bursa Fabricii and bursin in the ontogeny of the pineal biosynthetic activity in the chicken. J.Pineal Res., 1996, 21: 35-43.
87- Youbicier-Simo BJ, Boudard F., Mekaouche M., .Baylé J.D, Bastide M:
Specific abolition reversal of pituitary-adrenal activity and control of the humoral immunity in bursectomized chickens through highly dilute bursin. Intern. J. Immunopathol. Pharmacol., 1996; 9: 43-51.
88- Youbicier-Simo BJ, Boudard F., Cabaner C., Bastide M:
Biological effects of continuous exposure of embryos and young chickens to electromagnetics fields emmitted by video display units. Bioelectromagnetics, 1997, 18: 514-523.
89- Guennoun M, Boudard F, Cabaner C, Robbe Y., Dubois J.B., Bastide M.
Radioprotective effect of immunomediators in total body irradiated BALB/c mice according to the season.
Chronobiology International, 1997, 14 (Sup.1): 60.
90- Youbicier-Simo BJ, Boudard F., Guelati M., Mekaouche M., Baylé J.D, Bastide M: The role of the bursa of Fabricius and highly diluted bursin in neuroendocrine interactions in the chickens.
Signal and Images, Bastide M. Ed, Kluwer Academic Publisher, Dordrecht, Boston, London, 1997: 121-149.
91- Rodriguez E, Boudard F., Mallié M., Bastide J.M., Bastide M:
Murine macrophage elastolytic activity induced by Aspergillus fumigatus strains in vitro: evidence of the expression ,of two macrophage-induced protease genes; Can.J.Microbiol.,1997, 43: 649-657.
92- Bastide M., Lagache A.
A communication process: a new paradigm applied to high-dilution effects on the living body. Altern Ther Health Med. 1997 Jul;3(4):35-9.
93- Bastide M
Basic research on high dilution effects. in : Taddei C and Marotta P eds : High dilution effects on cells and integrated systems. World Scientific Publ. Singapore, New Jersey, London, 1998: 3-18.
94- Bastide M, Boudard F
High dilutions as a tool of immunomodulation. in : Taddei C and Marotta P eds : High dilution effects on cells and integrated systems. World Scientific Publ. Singapore, New Jersey, London, 1998, 165-175.
95- Bastide M, Lagache A
A new paradigm applied to high dilution effects on the living body. in : Taddei C and Marotta P eds : High dilution effects on cells and integrated systems. World Scientific Publ. Singapore, New Jersey, London, 1998, 335-345.
96- Bastide M
Information and communication in living organisms. In: Schultze J. and Endler P.C. eds: Fundamental Research in Ultra High Dilution and Homeopathy. Kluwer Academic Publisher, Dordrecht, Boston, London, 1998, 229-239.
97- Bastide M
Is the experimental method necessary to unconventional medicine basic research ? Example of Homeopathy. In Rapport programme européen COST B4, Unconventional Medicine in Europe, Basic Research Papers literature review, Working group Activity report, Van Wassenhoven Ed., 1998, (11 pages).
98- Bastide M
L'Homéopathie: méthode utilisée à l'échelle individuelle pour aider les fumeurs à arrêter leur consommation de tabac. In: "l'arrêt de la consommation du tabac", Conférence de Consensus, Assistance Publique/Hôpitaux de Paris eds, EDK Publisher, 1998, 209-216.
99- Guennoun M., Cabaner C., Boudard F., Robbe Y., Dubois J.B., Bastide M. Gamma rays total body irradiation effects on immune system of BALB/c mice: an immunopharmacology model for radioprotection study. Int J Immunopathol Pharmacol 1998 ; 11 : 11-16.
100- Bastide M., participation au livre « Larousse de l'Homéopathie », Larousse Publisher, Paris, 2000.
101- Bastide M., Youbicier-Simo B.J., Lebecq J.C., Giaimis J. Toxicological study of electromagnetic radiation emitted by television and video display units and cellular telephones on chickens and mice, Indoor Built Environ., 2001 : 10, 291-298.
102- Bastide M., « Recherche Fondamentale », in : A.Sarembaud, « Homéopathie », Série Abrégés, Masson Publisher, Paris, 2eme édition, 2002 : 221-235.

Papers published in National Journals : 40
International Communications and Posters: 88
National Communications and Posters 35
Invited lectures mainly on Homeopathy : 115